NKH 477 hydrochloride

CAS No. 138605-00-2

NKH 477 hydrochloride ( Colforsin dapropate )

Catalog No. M11605 CAS No. 138605-00-2

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NKH 477 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.
  • Description
    NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.Heart Failure Approveed
  • Synonyms
    Colforsin dapropate
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Adenylate Cyclase
  • Recptor
    Adenylate Cyclase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    138605-00-2
  • Formula Weight
    546.10
  • Molecular Formula
    C27H43NO8.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl
  • Chemical Name
    (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.
2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.
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