NKH 477 hydrochloride
CAS No. 138605-00-2
NKH 477 hydrochloride ( Colforsin dapropate )
Catalog No. M11605 CAS No. 138605-00-2
NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNKH 477 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.
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DescriptionNKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.Heart Failure Approveed
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SynonymsColforsin dapropate
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PathwayMetabolic Enzyme/Protease
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TargetAdenylate Cyclase
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RecptorAdenylate Cyclase
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Research Area——
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Indication——
Chemical Information
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CAS Number138605-00-2
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Formula Weight546.10
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Molecular FormulaC27H43NO8.HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl
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Chemical Name(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.
2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.
2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.
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